mutability in life or nature (especially successive alternation from one condition to another)
a variation in circumstances or fortune at different times in your life or in the development of something; "the project was subject to the usual vicissitudes of exploratory research"
not ever; at no time in the past or future; "I have never been to China"; "I shall never forget this day"; "had never seen a circus"; "never on Sunday"; "I will never marry you!"
not at all; certainly not; not in any circumstances; "never fear"; "bringing up children is never easy"; "that will never do"; "what is morally wrong can never be politically right"
deserving or inciting pity; "a hapless victim"; "miserable victims of war"; "the shabby room struck her as extraordinarily pathetic"- Galsworthy; "piteous appeals for help"; "pitiable homeless children"; "a pitiful fate"; "Oh, you poor thing"; "his poor distorted limbs"; "a wretched life"
loaded to excess or impeded by a heavy load; "a summer resort...encumbered with great clapboard-and-stucco hotels"- A.J.Liebling; "a hiker encumbered with a heavy backpack"; "an encumbered estate"