something that causes or entails suffering; "I cannot think it a hardship that more indulgence is allowed to men than to women"- James Boswell; "the many hardships of frontier life"
mutability in life or nature (especially successive alternation from one condition to another)
a variation in circumstances or fortune at different times in your life or in the development of something; "the project was subject to the usual vicissitudes of exploratory research"
something or someone that causes trouble; a source of unhappiness; "washing dishes was a nuisance before we got a dish washer"; "a bit of a bother"; "he's not a friend, he's an infliction"
an emotion of great sadness associated with loss or bereavement; "he tried to express his sorrow at her loss"
sadness associated with some wrong done or some disappointment; "he drank to drown his sorrows"; "he wrote a note expressing his regret"; "to his rue, the error cost him the game"