excite to an abnormal condition, of chafe or inflame; "Aspirin irritates my stomach"
excite to some characteristic action or condition, such as motion, contraction, or nervous impulse, by the application of a stimulus; "irritate the glands of a leaf"
an emotion of great sadness associated with loss or bereavement; "he tried to express his sorrow at her loss"
sadness associated with some wrong done or some disappointment; "he drank to drown his sorrows"; "he wrote a note expressing his regret"; "to his rue, the error cost him the game"