arouse hostility or indifference in where there had formerly been love, affection, or friendliness; "She alienated her friends when she became fanatically religious"
remove from customary environment or associations; "Her busy schedule removed her from her duties as a mother"
excite to an abnormal condition, of chafe or inflame; "Aspirin irritates my stomach"
excite to some characteristic action or condition, such as motion, contraction, or nervous impulse, by the application of a stimulus; "irritate the glands of a leaf"
earnest and conscientious activity intended to do or accomplish something; "made an effort to cover all the reading material"; "wished him luck in his endeavor"; "she gave it a good try"
reach a destination; arrive by movement or progress; "She arrived home at 7 o'clock"; "She didn't get to Chicago until after midnight"
succeed in a big way; get to the top; "After he published his book, he had arrived"; "I don't know whether I can make it in science!"; "You will go far, my boy!"