mutability in life or nature (especially successive alternation from one condition to another)
a variation in circumstances or fortune at different times in your life or in the development of something; "the project was subject to the usual vicissitudes of exploratory research"
difficult to penetrate; incomprehensible to one of ordinary understanding or knowledge; "the professor's lectures were so abstruse that students tended to avoid them"; "a deep metaphysical theory"; "some recondite problem in historiography"