something that causes or entails suffering; "I cannot think it a hardship that more indulgence is allowed to men than to women"- James Boswell; "the many hardships of frontier life"
mutability in life or nature (especially successive alternation from one condition to another)
a variation in circumstances or fortune at different times in your life or in the development of something; "the project was subject to the usual vicissitudes of exploratory research"
a plant that is native to a certain limited area; "it is an endemic found only this island"
a disease that is constantly present to a greater or lesser degree in people of a certain class or in people living in a particular location
native to or confined to a certain region; "the islands have a number of interesting endemic species"
of or relating to a disease (or anything resembling a disease) constantly present to greater or lesser extent in a particular locality; "diseases endemic to the tropics"; "endemic malaria"; "food shortages and starvation are endemic in certain parts of the world"