special and significant stress by means of position or repetition e.g.
special importance or significance; "the red light gave the central figure increased emphasis"; "the room was decorated in shades of grey with distinctive red accents"
something that causes or entails suffering; "I cannot think it a hardship that more indulgence is allowed to men than to women"- James Boswell; "the many hardships of frontier life"
mutability in life or nature (especially successive alternation from one condition to another)
a variation in circumstances or fortune at different times in your life or in the development of something; "the project was subject to the usual vicissitudes of exploratory research"