fill with apprehension or alarm; cause to be unpleasantly surprised; "I was horrified at the thought of being late for my interview"; "The news of the executions horrified us"
make (alcohol) unfit for drinking without impairing usefulness for other purposes
modify (as a native protein) especially by heat, acid, alkali, or ultraviolet radiation so that all of the original properties are removed or diminished
add nonfissionable material to (fissionable material) so as to make unsuitable for use in an atomic bomb