impervious to pleas, persuasion, requests, reason; "he is adamant in his refusal to change his mind"; "Cynthia was inexorable; she would have none of him"- W.Churchill; "an intransigent conservative opposed to every liberal tendency"
the occurrence of incoming water (between a low tide and the following high tide); "a tide in the affairs of men which, taken at the flood, leads on to fortune" -Shakespeare
make (alcohol) unfit for drinking without impairing usefulness for other purposes
modify (as a native protein) especially by heat, acid, alkali, or ultraviolet radiation so that all of the original properties are removed or diminished
add nonfissionable material to (fissionable material) so as to make unsuitable for use in an atomic bomb