something that causes or entails suffering; "I cannot think it a hardship that more indulgence is allowed to men than to women"- James Boswell; "the many hardships of frontier life"
mutability in life or nature (especially successive alternation from one condition to another)
a variation in circumstances or fortune at different times in your life or in the development of something; "the project was subject to the usual vicissitudes of exploratory research"
something or someone that causes trouble; a source of unhappiness; "washing dishes was a nuisance before we got a dish washer"; "a bit of a bother"; "he's not a friend, he's an infliction"
the quality of being difficult; "they agreed about the difficulty of the climb"
a factor causing trouble in achieving a positive result or tending to produce a negative result; "serious difficulties were encountered in obtaining a pure reagent"
a condition or state of affairs almost beyond one's ability to deal with and requiring great effort to bear or overcome; "grappling with financial difficulties"
in a manful manner; with qualities thought to befit a man; "having said her say Peggy manfully shouldered her burden and prepared to break up yet another home"
a situation from which extrication is difficult especially an unpleasant or trying one; "finds himself in a most awkward predicament"; "the woeful plight of homeless people"