something that comes into existence as a result; "industrialism prepared the way for acceptance of the French Revolution's various socialistic offspring"; "this skyscraper is the solid materialization of his efforts"
the immediate descendants of a person; "she was the mother of many offspring"; "he died without issue"
a book (or manuscript) consisting of large sheets of paper folded in the middle to make two leaves or four pages; "the first folio of Shakespeare's plays"