any disease of the mind; the psychological state of someone who has emotional or behavioral problems serious enough to require psychiatric intervention
place in a place where something cannot be removed or someone cannot escape; "The parents locked her daughter up for the weekend"; "She locked her jewels in the safe"
close with or as if with a tight seal; "This vacuum pack locks in the flavor!"
habitual intoxication; prolonged and excessive intake of alcoholic drinks leading to a breakdown in health and an addiction to alcohol such that abrupt deprivation leads to severe withdrawal symptoms