charge falsely or with malicious intent; attack the good name and reputation of someone; "The journalists have defamed me!" "The article in the paper sullied my reputation"
a state of extreme (usually irremediable) ruin and misfortune; "lack of funds has resulted in a catastrophe for our school system"; "his policies were a disaster"
cause annoyance in; disturb, especially by minor irritations; "Mosquitoes buzzing in my ear really bothers me"; "It irritates me that she never closes the door after she leaves"