make (alcohol) unfit for drinking without impairing usefulness for other purposes
modify (as a native protein) especially by heat, acid, alkali, or ultraviolet radiation so that all of the original properties are removed or diminished
add nonfissionable material to (fissionable material) so as to make unsuitable for use in an atomic bomb
the state of needing something that is absent or unavailable; "there is a serious lack of insight into the problem"; "water is the critical deficiency in desert regions"; "for want of a nail the shoe was lost"