in a manful manner; with qualities thought to befit a man; "having said her say Peggy manfully shouldered her burden and prepared to break up yet another home"
(pharmacology) a book containing a compilation of pharmaceutical products with their formulas and methods of preparation; "postexposure prophylaxis is an integral part of the pharmacopeia in preventing severe disease after acute infections"
something that causes or entails suffering; "I cannot think it a hardship that more indulgence is allowed to men than to women"- James Boswell; "the many hardships of frontier life"