arouse hostility or indifference in where there had formerly been love, affection, or friendliness; "She alienated her friends when she became fanatically religious"
remove from customary environment or associations; "Her busy schedule removed her from her duties as a mother"
excite to an abnormal condition, of chafe or inflame; "Aspirin irritates my stomach"
excite to some characteristic action or condition, such as motion, contraction, or nervous impulse, by the application of a stimulus; "irritate the glands of a leaf"