mutability in life or nature (especially successive alternation from one condition to another)
a variation in circumstances or fortune at different times in your life or in the development of something; "the project was subject to the usual vicissitudes of exploratory research"
not sympathetic or disposed toward; "unsympathetic officialdom"; "people unsympathetic to the revolution"; "his dignity made him seem aloof and unsympathetic"
(of characters in literature or drama) tending to evoke antipathetic feelings; "all the characters were peculiarly unsympathetic"
harshly uninviting or formidable in manner or appearance; "a dour, self-sacrificing life"; "a forbidding scowl"; "a grim man loving duty more than humanity"; "undoubtedly the grimmest part of him was his iron claw"- J.M.Barrie
not changeable or subject to change; "a fixed and unchangeable part of the germ plasm"-Ashley Montagu; "the unchangeable seasons"; "one of the unchangeable facts of life"
precisely determined or limited or defined; especially fixed by rule or by a specific and constant cause; "a determinate distance"; "a determinate number"; "determinate variations in animals"
not continuing to grow indefinitely at the apex; "determinate growth"