a state of extreme (usually irremediable) ruin and misfortune; "lack of funds has resulted in a catastrophe for our school system"; "his policies were a disaster"
(Hinduism and Buddhism) the beatitude that transcends the cycle of reincarnation; characterized by the extinction of desire and suffering and individual consciousness
cause annoyance in; disturb, especially by minor irritations; "Mosquitoes buzzing in my ear really bothers me"; "It irritates me that she never closes the door after she leaves"